A recent investigation utilizing the UK Biobank cohort has revealed a correlation between consistent coffee or caffeine consumption, particularly at moderate quantities, and a diminished likelihood of developing new-onset cardiometabolic multimorbidity. This condition is characterized by the concurrent presence of at least two distinct cardiometabolic ailments.
Lu et al. determined that habitual coffee or caffeine ingestion, especially in moderate amounts, was linked to a reduced incidence of new-onset cardiometabolic multimorbidity. Image attribution: Sci.News.
“Cardiometabolic multimorbidity (CM) represents a growing challenge to public health,” commented Dr. Chaofu Ke, affiliated with Suzhou Medical College at Soochow University, and his associates.
“Prior observational studies have indicated an inverse relationship between the intake of coffee, tea, and caffeine, and the risks associated with individual cardiometabolic diseases.”
“However, their associations with CM and the relevant biological markers remain unexplored.”
The prospective analysis encompassed 172,315 individuals (for caffeine-related analyses) and 188,091 individuals (for tea and coffee consumption analyses) who were free from any cardiometabolic diseases at the study’s commencement, drawn from the UK Biobank database.
The researchers ascertained that individuals consuming a moderate amount of coffee (equivalent to 3 cups daily) or caffeine (ranging from 200-300 mg per day) experienced a 48.1% or 40.7% reduction in the risk of new-onset CM, respectively, when compared to non-consumers or those ingesting less than 100 mg of caffeine daily.
“We disqualified participants who provided unclear information regarding their caffeine intake,” the authors clarified.
“The resultant participant pool comprised a total of 172,315 individuals free of any cardiometabolic diseases at baseline for the caffeine-related analyses, and a corresponding 188,091 individuals for the analyses pertaining to coffee and tea consumption.”
“The identification of participants’ cardiometabolic disease outcomes was derived from self-reported medical conditions, primary care records, linked inpatient hospital data, and mortality registry information connected to the UK Biobank.”
Across all consumption levels, coffee and caffeine intake demonstrated an inverse association with the incidence of new-onset CM among participants without pre-existing cardiometabolic diseases.
The lowest risk was observed in those individuals who reported moderate consumption of coffee or caffeine.
Moderate consumption of coffee or caffeine was inversely correlated with nearly all stages of CM development.
“The consumption of approximately three cups of coffee, or 200-300 mg of caffeine, daily could potentially contribute to mitigating the risk of developing cardiometabolic multimorbidity in individuals who do not currently have any cardiometabolic conditions,” stated Dr. Ke.
These findings have been formally published in the Journal of Clinical Endocrinology & Metabolism.
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Xujia Lu et al. Habitual Coffee, Tea, and Caffeine Consumption, Circulating Metabolites, and the Risk of Cardiometabolic Multimorbidity. Journal of Clinical Endocrinology & Metabolism, released on September 17, 2024; doi: 10.1210/clinem/dgae552
